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J Infect Dis. 2014 Jun 15;209(12):1916-20. doi: 10.1093/infdis/jiu026. Epub 2014 Jan 16.

Sensitive tenofovir resistance screening of HIV-1 from the genital and blood compartments of women with breakthrough infections in the CAPRISA 004 tenofovir gel trial.

Author information

1
Centers for Disease Control and Prevention, Atlanta, Georgia.
2
National Institute for Communicable Diseases.
3
Department of Epidemiology, Columbia University, New York, New York CAPRISA-Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban.
4
CAPRISA-Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban.
5
Eshelman School of Pharmacy, University of North Carolina, Chapel Hill.
6
National Health Laboratory Service, Johannesburg CAPRISA-Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban.

Abstract

The Centre for the AIDS Programme of Research in South Africa 004 (CAPRISA 004) study demonstrated that vaginally applied tenofovir gel is a promising intervention for protecting women from sexually acquiring human immunodeficiency virus (HIV). However, the potential for emergence of tenofovir resistance remains a concern in women who seroconvert while using the gel despite the lack of plasma virus resistance as assessed by population sequencing during the trial. We applied highly sensitive polymerase chain reaction-based assays to screen for tenofovir resistance in plasma and vaginal swab specimens. The absence of mutation detection suggested little immediate risk of tenofovir-resistant HIV-1 emergence and forward transmission in settings in which gel users are closely monitored for HIV seroconversion.

KEYWORDS:

HIV prevention; Vaginal microbicide; pre-exposure prophylaxis; tenofovir gel; topical PrEP

PMID:
24436453
PMCID:
PMC4038144
DOI:
10.1093/infdis/jiu026
[Indexed for MEDLINE]
Free PMC Article
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