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Muscle Nerve. 2014 Sep;50(3):413-6. doi: 10.1002/mus.24178. Epub 2014 Jun 16.

One-minute exercise is best for evaluation of postexercise exhaustion in myasthenia gravis.

Author information

1
Department of Neurology, University of Alabama at Birmingham, UAB Station, Birmingham, Alabama, USA, 35294.

Abstract

INTRODUCTION:

To find the best exercise duration for postexercise exhaustion by decrement (PEE-D) in myasthenia gravis (MG).

METHODS:

In 32 tests in 32 MG patients, repetitive nerve stimulation was performed in the abductor digiti quinti muscle. The 3 Hz responses for 2 s were obtained with supramaximal stimulation at rest, and immediately after (PE0), 30 s after (PE30s), and 1, 2, 3, and 4 min after 10-s, 30-s, and 1-min exercises.

RESULTS:

Compared with the decrement at rest, a significantly greater decrement was found at PE2m and PE3m after 30-s exercise, and at PE2m, PE3m, and PE4m after 1-min exercise. In 11 patients who showed a decremental response only with exercise, PEE-D was observed in 5 after 30-s exercise and in 8 after 1-min exercise.

CONCLUSIONS:

One-minute exercise is best for evaluation of PEE-D in MG.

KEYWORDS:

MG; Myasthenia gravis; Repetitive nerve stimulation test; decremental response; postexercise exhaustion

PMID:
24435816
DOI:
10.1002/mus.24178
[Indexed for MEDLINE]

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