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Sci Rep. 2014 Jan 17;4:3741. doi: 10.1038/srep03741.

Relationship between Plasmodium falciparum malaria prevalence, genetic diversity and endemic Burkitt lymphoma in Malawi.

Author information

1
University of York, York, United Kingdom.
2
Frederick National Laboratory for Cancer Research, Frederick, Maryland.
3
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
4
Queen Elizabeth Hospital, Blantyre, Malawi.
5
University of Oxford, Oxford, UK.

Abstract

Endemic Burkitt lymphoma (eBL) has been linked to Plasmodium falciparum (Pf) malaria infection, but the contribution of infection with multiple Pf genotypes is uncertain. We studied 303 eBL (cases) and 274 non eBL-related cancers (controls) in Malawi using a sensitive and specific molecular-barcode array of 24 independently segregating Pf single nucleotide polymorphisms. Cases had a higher Pf malaria prevalence than controls (64.7% versus 45.3%; odds ratio [OR] 2.1, 95% confidence interval (CI): 1.5 to 3.1). Cases and controls were similar in terms of Pf density (4.9 versus 4.5 log copies, p = 0.28) and having ≥3 non-clonal calls (OR 2.7, 95% CI: 0.7-9.9, P = 0.14). However, cases were more likely to have a higher Pf genetic diversity score (153.9 versus 133.1, p = 0.036), which measures a combination of clonal and non-clonal calls, than controls. Further work is needed to evaluate the possible role of Pf genetic diversity in the pathogenesis of endemic BL.

PMID:
24434689
PMCID:
PMC3894552
DOI:
10.1038/srep03741
[Indexed for MEDLINE]
Free PMC Article

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