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Curr Opin Neurobiol. 2014 Jun;26:64-71. doi: 10.1016/j.conb.2013.12.009. Epub 2014 Jan 14.

Autaptic self-inhibition of cortical GABAergic neurons: synaptic narcissism or useful introspection?

Author information

1
ICM - Institut du Cerveau et de la Moelle épinière, Groupe Hospitalier Pitié Salpêtrière, 47 Boulevard de l'Hopital, 75013 Paris, France.
2
European Brain Research Institute, Rome, Italy.
3
ICM - Institut du Cerveau et de la Moelle épinière, Groupe Hospitalier Pitié Salpêtrière, 47 Boulevard de l'Hopital, 75013 Paris, France; Centre National de la Recherche Scientifique Unité Mixte de Recherche 7225, Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche 975, Université Pierre et Marie Curie - Paris 6, 75005 Paris, France. Electronic address: alberto.bacci@icm-institute.org.

Abstract

Fast synaptic inhibition sculpts all forms of cortical activity by means of a specialized connectivity pattern between highly heterogeneous inhibitory interneurons and principal excitatory cells. Importantly, inhibitory neurons connect also to each other extensively, following a detailed blueprint, and, indeed, specific forms of disinhibition affect important behavioral functions. Here we discuss a peculiar form of cortical disinhibition: the massive autaptic self-inhibition of parvalbumin-(PV) positive basket cells. Despite being described long ago, autaptic inhibition onto PV basket cells is rarely included in cortical circuit diagrams, perhaps because of its still elusive function. We propose here a potential dual role of autaptic feedback inhibition in temporally coordinating PV basket cells during cortical network activity.

PMID:
24434607
DOI:
10.1016/j.conb.2013.12.009
[Indexed for MEDLINE]

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