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J Neuroimmunol. 2014 Feb 15;267(1-2):16-9. doi: 10.1016/j.jneuroim.2013.11.007. Epub 2013 Dec 6.

Soluble complement complex C5b-9 promotes microglia activation.

Author information

1
Department of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
2
Department of Cardiology, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
3
Department of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China. Electronic address: lzsht@aliyun.com.

Abstract

Soluble C5b-9 has been described as a pro-inflammatory mediator that triggers cell activation rather than inducing cell death. Microglia is the most important immune cell involved in inflammatory response in the CNS. Although microglia activation induced by various stimuli has been well characterized, the role of C5b-9 in microglia has not been well studied. In the current experiment, we utilized assembled functional C5b-9 to treat microglia and analyzed the function. We found that soluble C5b-9 could promote microglia activation by up-regulation of costimulatory molecules and increase cytokine secretion. Our results suggested that soluble C5b-9 possessed immunoregulatory potential on microglia.

KEYWORDS:

Activation; C5b-9; Microglia

PMID:
24434076
DOI:
10.1016/j.jneuroim.2013.11.007
[Indexed for MEDLINE]

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