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Cytokine Growth Factor Rev. 2014 Apr;25(2):147-56. doi: 10.1016/j.cytogfr.2013.12.002. Epub 2013 Dec 25.

Roles for TNF-receptor associated factor 3 (TRAF3) in lymphocyte functions.

Author information

1
Department of Microbiology, The University of Iowa, USA.
2
The Graduate Program in Immunology, The University of Iowa, USA.
3
Department of Microbiology, The University of Iowa, USA; The Graduate Program in Immunology, The University of Iowa, USA; Department of Internal Medicine, The University of Iowa, USA; Veterans Affairs Medical Center, Iowa City, IA 52242, USA. Electronic address: gail-bishop@uiowa.edu.

Abstract

TRAF3 is an adapter protein that serves and regulates the functions of several types of receptors, located both inside the cell and at the plasma membrane. These include members of the TNF receptor superfamily (TNFR-SF), toll-like receptors (TLR), and cytokine receptors. It has become increasingly evident that the roles and functions of TRAF3 are highly context-dependent. TRAF3 can serve distinct roles for different receptors in the same cell, and also has highly cell-type-dependent functions. This review focuses upon the current state of knowledge regarding how TRAF3 regulates the biology and effector functions of B and T lymphocytes, two major cell types of the adaptive immune response in which TRAF3 has markedly distinct roles.

KEYWORDS:

B lymphocyte; Lymphocyte activation; Signal transduction; T lymphocyte; TRAF

PMID:
24433987
PMCID:
PMC3999169
DOI:
10.1016/j.cytogfr.2013.12.002
[Indexed for MEDLINE]
Free PMC Article

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