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J Int AIDS Soc. 2014 Jan 9;17:18773. doi: 10.7448/IAS.17.1.18773. eCollection 2014.

High prevalence of low bone mass and associated factors in Korean HIV-positive male patients undergoing antiretroviral therapy.

Author information

1
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
2
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; molder@unitel.co.kr.

Abstract

INTRODUCTION:

Low bone mass is prevalent in HIV-positive patients. However, compared to Western countries, less is known about HIV-associated osteopenia in Asian populations.

METHODS:

We performed a cross-sectional survey in Seoul National University Hospital from December 2011 to May 2012. We measured bone mineral density using central dual energy X-ray absorptiometry, with consent, in male HIV-positive patients, aged 40 years and older. Diagnosis of low bone mass was made using International Society for Clinical Densitometry Z-score criteria in the 40-49 years age group and World Health Organization T-score criteria in the >50-year age group. The data were compared with those of a community-based cohort in Korea.

RESULTS:

Eighty-four HIV-positive male patients were included in this study. Median age was 49 (interquartile range [IQR], 45-56) years, and median body mass index (BMI) was 22.6 (IQR, 20.9-24.4). Viral suppression was achieved in 75 (89.3%) patients and median duration of antiretroviral therapy was 71 (IQR, 36-120) months. The overall prevalence of low bone mass was 16.7% in the 40-49 years age group and 54.8% in the>50 years age group. Our cohort had significantly lower bone mass at the femur neck and total hip than HIV-negative Koreans in the 40-49 years age group. Low bone mass was significantly associated with low BMI, and a high level of serum carboxy-terminal collagen crosslinks, but was not associated with antiretroviral regimen or duration of antiretroviral therapy.

CONCLUSIONS:

Low bone mass is prevalent in Korean HIV-positive males undergoing antiretroviral therapy, and may be associated with increased bone resorption.

KEYWORDS:

AIDS; HIV; osteopenia; osteoporosis

PMID:
24433984
PMCID:
PMC3888902
DOI:
10.7448/IAS.17.1.18773
[Indexed for MEDLINE]
Free PMC Article

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