Evidence based practice (EBP) can be incorporated into the curriculum of Medical Laboratory Science (MLS) Programs. Current components of curriculum can include EBP in pre-analytic, analytic, and post-analytic topics. Discussion of EBP topics in the classroom using practices assessed through the Laboratory Medicine Best Practices Initiative (LMBP) of the U.S. Centers for Disease Control and Prevention will give students a clear understanding of EBP and how it is used in the clinical laboratory for improved health care quality. Student involvement in Quality Improvement projects to improve laboratory performance and patient outcomes can be developed through capstone projects. Examples of clinical projects and application of EBP into the MLS curriculum are discussed.