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Acta Biochim Pol. 2013;60(4):871-3.

Prp4 kinase is required for proper segregation of chromosomes during meiosis in Schizosaccharomyces pombe.

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Slovak University of Agriculture, Department of Genetics and Breeding Biology, Nitra, Slovakia.
Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Slovakia.


Chromosome segregation during meiosis is a complex process, which leads to production of four haploid gametes from two precursor cells. Reversible phosphorylation of proteins plays a crucial role in this process. The Schizosaccharomyces pombe Prp4 is an essential serine/threonine protein kinase, which belongs to the Clk/Sty family. To study the role of Prp4 in meiosis, we analysed chromosome segregation in a strain carrying conditional analog-sensitive allele of Prp4 protein kinase (prp4-as2). Our data show, that Prp4 protein kinase plays important role in chromosome segregation during meiosis, as revealed by enhanced missegregation of chromosomes in prp4-as2 mutant cells.

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