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J Vet Med Sci. 2014 May;76(5):757-61. Epub 2014 Jan 16.

N-acetyl-D-mannosamine treatment alleviates age-related decline in place-learning ability in dogs.

Author information

1
Department of Animal Science and Biotechnology, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.

Abstract

This study aimed to investigate the therapeutic effects of N-acetyl-D-mannosamine (ManNAc) on age-related cognitive dysfunction in dogs. ManNAc was administered to 5 dogs with low cognitive levels for 2 months, and the cognitive ability and active-resting cycle were periodically assessed for improvement. ManNAc treatment significantly reduced the number of error trials in the place-learning test, especially in the first month of administration. Three ManNAc-treated dogs also showed improvement in the active-resting cycle. In conclusion, ManNAc treatment appears to alleviate age-related cognitive dysfunction.

PMID:
24430654
PMCID:
PMC4073348
DOI:
10.1292/jvms.13-0351
[Indexed for MEDLINE]
Free PMC Article

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