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Pediatr Res. 2014 Mar;75(3):376-80. doi: 10.1038/pr.2013.238. Epub 2013 Dec 12.

Intermittent or sustained systemic inflammation and the preterm brain.

Author information

1
1] Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts [2] Division of Newborn Medicine, Department of Neurology, Floating Hospital for Children at Tufts Medical Center,, Boston, Massachusetts [3] Perinatal Neuroepidemiology Unit, Hannover Medical School, Hannover, Germany.
2
Neuroepidemiology Unit, Children's Hospital, Boston, Massachusetts.

Abstract

Exposure to perinatal infection and inflammation is associated with an increased risk for neonatal brain damage and developmental disabilities. In this integrated mechanism review, we discuss evidence in support of the contention that the preterm newborn is capable of intermittent or sustained systemic inflammation (ISSI), which appears to contribute more to adverse neurodevelopmental outcomes in preterm infants than does shorter duration inflammation.

PMID:
24429547
PMCID:
PMC3943674
DOI:
10.1038/pr.2013.238
[Indexed for MEDLINE]
Free PMC Article

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