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J Rheumatol. 2014 Mar;41(3):523-7. doi: 10.3899/jrheum.130823. Epub 2014 Jan 15.

The microanatomic basis of finger clubbing - a high-resolution magnetic resonance imaging study.

Author information

1
From the UK National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK; Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan; Department of Radiology, Faculty of Medicine, Shimane University, Shimane, Japan; Medical Physics and Engineering, Leeds Teaching Hospitals UK National Health Service (NHS) Trust, Leeds, UK.

Abstract

OBJECTIVE:

Hypervascularization in finger clubbing is recognized, but its microanatomical basis remains unclear. This pilot descriptive study used magnetic resonance imaging (MRI) to explore this further.

METHODS:

High-resolution MRI acquired with contrast agent was carried out in 4 patients with finger clubbing and 4 healthy volunteers. The anatomy of the nail bed, capsular structures, and bony changes were described.

RESULTS:

Marked nail bed thickening and contrast enhancement was noted in all clubbed fingers, with bone edema in 3 of the 4 patients. None of the healthy subjects had similar abnormalities.

CONCLUSION:

This confirms that hypervascularization of the nail bed observed in the microanatomy on high-resolution MRI is associated with clubbed appearances of the nails.

KEYWORDS:

CANCER; FINGER CLUBBING; LUNG; MAGNETIC RESONANCE IMAGING; NAIL; RESPIRATORY

PMID:
24429181
DOI:
10.3899/jrheum.130823
[Indexed for MEDLINE]

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