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Diagn Microbiol Infect Dis. 2014 Mar;78(3):292-4. doi: 10.1016/j.diagmicrobio.2013.12.003. Epub 2013 Dec 14.

Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing β-lactamases in Pseudomonas aeruginosa in Turkey.

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Department of Medical Microbiology, Faculty of Medicine, Bezmialem Vakıf University, Istanbul, Turkey.
Department of Genetics and Bioengineering, Faculty of Engineering and Natural Sciences, Gümüşhane University, 29100 Gumushane, Turkey.
Department of Medical Microbiology, Recep Tayyip Erdogan University Faculty of Medicine, Rize, Turkey.
Service de Bactériologie-Virologie, INSERM U914, Emerging resistance to antibiotics, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris Sud, K-Bicêtre, France.
Department of Biology, Faculty of Arts & Sciences, Artvin Coruh University, 08000 Artvin, Turkey.
Department of Biology, Faculty of Arts & Sciences, Recep Tayyip Erdogan University, Rize, Turkey. Electronic address:


Pseudomonas aeruginosa isolates were collected form a Turkish hospital. Antimicrobial susceptibility was performed using the Vitek 2 Compact system, and 24 isolates were categorized as multidrug resistant (n = 18), extensively-drug resistant (n = 5), or pan-drug resistant (n = 1). PCR and DNA sequence analysis revealed that 1 strain possessed the blaGES-5 and another carried a novel blaVIM variant, named VIM-38. This new gene exhibited 1 amino acid substitution (Ala265Val) in comparison to its closest variant, VIM-5. Both VIM encoding genes were clones and demonstrated similar susceptibility profile when expressed in identical background. The presence of VIM-38 increases the diversity of carbapenemases in Turkey.


Carbapenemase; Class 1 integron; ESBL; Pseudomonas aeruginosa; β-lactamase

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