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J Am Chem Soc. 2014 Jan 29;136(4):1300-3. doi: 10.1021/ja412342g. Epub 2014 Jan 15.

Simple, chemoselective hydrogenation with thermodynamic stereocontrol.

Author information

1
Department of Chemistry, The Scripps Research Institute , La Jolla, California 92037, United States.

Abstract

Few methods permit the hydrogenation of alkenes to a thermodynamically favored configuration when steric effects dictate the alternative trajectory of hydrogen delivery. Dissolving metal reduction achieves this control, but with extremely low functional group tolerance. Here we demonstrate a catalytic hydrogenation of alkenes that affords the thermodynamic alkane products with remarkably broad functional group compatibility and rapid reaction rates at standard temperature and pressure.

PMID:
24428640
PMCID:
PMC3951266
DOI:
10.1021/ja412342g
[Indexed for MEDLINE]
Free PMC Article

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