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J Clin Sleep Med. 2014 Jan 15;10(1):49-56. doi: 10.5664/jcsm.3358.

Impact of dronabinol on quantitative electroencephalogram (qEEG) measures of sleep in obstructive sleep apnea syndrome.

Author information

1
Center for Narcolepsy, Sleep and Health Research.
2
Center for Narcolepsy, Sleep and Health Research ; Department of Medicine.
3
Department of Biobehavioral Health Science.
4
Center for Narcolepsy, Sleep and Health Research ; Department of Medicine ; Department of Biobehavioral Health Science ; Department of Bioengineering, University of Illinois at Chicago, Chicago, IL.

Abstract

STUDY OBJECTIVES:

To determine the effects of dronabinol on quantitative electroencephalogram (EEG) markers of the sleep process, including power distribution and ultradian cycling in 15 patients with obstructive sleep apnea (OSA).

METHODS:

EEG (C4-A1) relative power (% total) in the delta, theta, alpha, and sigma bands was quantified by fast Fourier transformation (FFT) over 28-second intervals. An activation ratio (AR = [alpha + sigma] / [delta + theta]) also was computed for each interval. To assess ultradian rhythms, the best-fitting cosine wave was determined for AR and each frequency band in each polysomnogram (PSG).

RESULTS:

Fifteen subjects were included in the analysis. Dronabinol was associated with significantly increased theta power (p = 0.002). During the first half of the night, dronabinol decreased sigma power (p = 0.03) and AR (p = 0.03), and increased theta power (p = 0.0006). At increasing dronabinol doses, ultradian rhythms accounted for a greater fraction of EEG power variance in the delta band (p = 0.04) and AR (p = 0.03). Females had higher amplitude ultradian rhythms than males (theta: p = 0.01; sigma: p = 0.01). Decreasing AHI was associated with increasing ultradian rhythm amplitudes (sigma: p < 0.001; AR: p = 0.02). At the end of treatment, lower relative power in the theta band (p = 0.02) and lower AHI (p = 0.05) correlated with a greater decrease in sleepiness from baseline.

CONCLUSIONS:

This exploratory study demonstrates that in individuals with OSA, dronabinol treatment may yield a shift in EEG power toward delta and theta frequencies and a strengthening of ultradian rhythms in the sleep EEG.

KEYWORDS:

Dronabinol; OSA; quantitative EEG; sleep; ultradian rhythms

PMID:
24426820
PMCID:
PMC3869068
DOI:
10.5664/jcsm.3358
[Indexed for MEDLINE]
Free PMC Article

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