Format

Send to

Choose Destination
See comment in PubMed Commons below
J Clin Sleep Med. 2014 Jan 15;10(1):7-11. doi: 10.5664/jcsm.3346.

Periodic limb movements during sleep and cardiac arrhythmia in older men (MrOS sleep).

Author information

1
Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, OH.
2
Department of Pulmonary, Critical Care and Sleep Medicine, Case Western Reserve University School of Medicine, Cleveland, OH.
3
Research Institute, California Pacific Medical Center, San Francisco, CA.
4
Department of Psychiatry, University of California, San Diego, La Jolla, CA.
5
Department of Medicine, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

Abstract

STUDY OBJECTIVES:

To determine if periodic limb movements during sleep (PLMS) are associated with nocturnal cardiac arrhythmia.

METHODS:

2,793 community-dwelling older men underwent polysomnography with measurement of limb movements and EKG. Logistic regression assessed association of periodic limb movement index and periodic limb movement arousal index with arrhythmia including atrial fibrillation and non-sustained ventricular tachycardia detected by polysomnography. Models were adjusted for age, race, cardiovascular risk factors, and clinic site. Secondary analyses were subset to men without calcium channel/β-adrenergic medication usage, and stratified by congestive heart failure or myocardial infarction history.

RESULTS:

In the overall cohort, periodic limb movement index, and periodic limb movement arousal index were not associated with ventricular or atrial arrhythmia after considering potential confounders. In men not taking calcium channel/β-blocking medication, increased adjusted odds of non-sustained ventricular tachycardia were observed for periodic limb movement index (OR = 1.30 per SD increase; 95% CI 1.00, 1.68) and periodic limb movement arousal index (OR = 1.29 per SD increase; 95% CI 1.03, 1.62). In men with CHF or MI, there was a suggested association of atrial fibrillation with periodic limb movement index (OR = 1.29, 95% CI 0.96, 1.73 per SD increase; p = 0.09) or periodic limb movement arousal index (OR = 1.21, 95% CI 0.94, 1.57 per SD increase; p = 0.14), although results were not statistically significant.

CONCLUSIONS:

There is not an association between PLMS and cardiac arrhythmia in all older men but in subsets of men, particularly those with structural heart disease and not on calcium channel or β-adrenergic medication, cardiac arrhythmia does associate with PLMS.

KEYWORDS:

PLMS; arrhythmia; cardiac; leg; periodic

PMID:
24426814
PMCID:
PMC3869072
DOI:
10.5664/jcsm.3346
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Academy of Sleep Medicine Icon for PubMed Central
    Loading ...
    Support Center