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Indian J Clin Biochem. 2013 Oct;28(4):358-60. doi: 10.1007/s12291-013-0296-1. Epub 2013 Jan 12.

Cytotoxicity of liposomal Paclitaxel in breast cancer cell line mcf-7.

Author information

1
Department of Chemical Engineering, Lamerd Branch, Islamic Azad University, Lamerd, Iran.
2
Department of Pilot Biotechnology, Pasteur Institute of Iran, Tehran, Iran.

Abstract

Regarding that the breast cancer is the most prevalent disease among women, paclitaxel, an anti-cancer drug, could be used in treatment of this disease. As paclitaxel has adverse effects, it was used of nanoliposome drug delivery technology in order to reduce adverse effects and improve drug efficacy. Certain ratios of phosphatidylcholine, cholesterol and paclitaxel were synthesized to prepare nanoliposomal paclitaxel. Using Zeta sizer device, the mean diameter of nanoliposomal paclitaxel was obtained 421.4 nm and its encapsulation efficiency was 91.3 %. By dialysis, drug release in nanoliposome paclitaxel formulation within 28 h was studied which was 5.53 %. This study showed that cytotoxicity effect of nanoliposomal paclitaxel is more than that of the standard form.

KEYWORDS:

Breast cancer; Nano drug delivery; Nanoliposome; Paclitaxel

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