Format

Send to

Choose Destination
See comment in PubMed Commons below
Indian J Clin Biochem. 2013 Apr;28(2):147-51. doi: 10.1007/s12291-012-0240-9. Epub 2012 Jul 28.

Importance of Serum Copper and Vascular Endothelial Growth Factor (VEGF-A) Levels in Postmenopausal Bleeding.

Author information

1
Department of Biochemistry, Kamineni Institute of Medical Sciences, Sreepuram, Narkatpally, Nalgonda, 508 254 Andhra Pradesh India.
2
Chalmeda Anandrao Institute of Medical Sciences, Bommakal, Karimnagar, Andhra Pradesh India.
3
Department of Biochemistry, Kasturba Medical College, Manipal University, Manipal, 576104 Karnataka India.

Abstract

The main aim of this study is association of serum copper and vascular endothelial growth factor (VEGF-A) in postmenopausal bleeding (PMB) patients. Blood samples were collected from female patients suffering with postmenopausal bleeding (n = 50) as well as healthy females as controls (n = 50). Serum copper levels were estimated by spectrophotometric method and serum VEGF-A by ELISA technique and compared with ultrasonographic measurement of endometrial thickness in both patients and controls. A significant increase in serum copper levels and an almost twofold increase in serum VEGF-A was observed in DUB patients when compared with controls. Correlation (r) between serum VEGF-A levels and endometrial thickness was 0.96. Odds ratio for copper, VEGF-A and combination of copper and VEGF-A was 0.0426, 0.0947 and 0.0313 respectively, in all these cases odds ratio was <1. The abnormal angiogenesis in PMB could be due to increased serum copper levels,which in turn stimulates factors like VEGF-A, thereby causing an increase in endometrial growth.

KEYWORDS:

ELISA; Postmenopausal bleeding; Serum copper; VEGF-A; Vascular endothelial growth factor

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center