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J Cell Sci. 2014 Mar 1;127(Pt 5):1052-1064. doi: 10.1242/jcs.141226. Epub 2014 Jan 14.

Podosomes of dendritic cells facilitate antigen sampling.

Author information

1
Department of Tumor Immunology Radboud University Medical Centre Radboud Centre for Molecular Life Sciences Geert Grooteplein 28 6525GA Nijmegen The Netherlands.
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Contributed equally

Abstract

Dendritic cells sample the environment for antigens and play an important role in establishing the link between innate and acquired immunity. Dendritic cells contain mechanosensitive adhesive structures called podosomes that consist of an actin-rich core surrounded by integrins, adaptor proteins and actin network filaments. They facilitate cell migration via localized degradation of extracellular matrix. Here, we show that podosomes of human dendritic cells locate to spots of low physical resistance in the substrate (soft spots) where they can evolve into protrusive structures. Pathogen recognition receptors locate to these protrusive structures where they can trigger localized antigen uptake, processing and presentation to activate T-cells. Our data demonstrate a novel role in antigen sampling for the podosomes of dendritic cells.

KEYWORDS:

Antigen presentation; Dendritic cell; Podosome; Receptor-mediated endocytosis

PMID:
24424029
PMCID:
PMC4054684
DOI:
10.1242/jcs.141226
[Indexed for MEDLINE]
Free PMC Article

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