Adrenocortical carcinoma

Endocr Rev. 2014 Apr;35(2):282-326. doi: 10.1210/er.2013-1029. Epub 2013 Dec 20.

Abstract

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy, often with an unfavorable prognosis. Here we summarize the knowledge about diagnosis, epidemiology, pathophysiology, and therapy of ACC. Over recent years, multidisciplinary clinics have formed and the first international treatment trials have been conducted. This review focuses on evidence gained from recent basic science and clinical research and provides perspectives from the experience of a large multidisciplinary clinic dedicated to the care of patients with ACC.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adrenal Cortex Neoplasms / diagnosis
  • Adrenal Cortex Neoplasms / epidemiology
  • Adrenal Cortex Neoplasms / physiopathology*
  • Adrenal Cortex Neoplasms / therapy
  • Adrenocortical Carcinoma / diagnosis
  • Adrenocortical Carcinoma / epidemiology
  • Adrenocortical Carcinoma / physiopathology*
  • Adrenocortical Carcinoma / therapy
  • Genetic Predisposition to Disease / epidemiology
  • Humans
  • Prevalence