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J Neuroophthalmol. 2014 Jun;34(2):169-72. doi: 10.1097/WNO.0000000000000096.

Papilledema as the initial presentation of Castleman disease.

Author information

1
Department of Ophthalmology (GT), Eye and ENT Hospital, Fudan University, Shanghai, China; and Departments of Neurology (YJ, HJ, XZ) and Hematology (JW), Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Abstract

Castleman disease is a rare lymphoproliferative disorder that has many presentations ranging from unifocal or multifocal mass lesions to a monoclonal gammopathy. It has features that may overlap with osteosclerotic myeloma or POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes) syndrome. We report a patient with papilledema, enlarged lymph nodes, and monoclonal IgG, who subsequently developed a polyneuropathy. Biopsy of enlarged mediastinal lymph nodes confirmed the diagnosis of Castleman disease.

PMID:
24423600
DOI:
10.1097/WNO.0000000000000096
[Indexed for MEDLINE]

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