Format

Send to

Choose Destination
Mol Biol Rep. 2014;41(4):1985-92. doi: 10.1007/s11033-014-3046-4. Epub 2014 Jan 14.

Grb10 is a dual regulator of receptor tyrosine kinase signaling.

Author information

1
Laboratory of Computational Biochemistry, KN Biomedical Research Institute, Bagura Road, Barisal, Bangladesh.

Abstract

The adaptor protein Grb10 is a close homolog of Grb7 and Grb14. These proteins are characterized by an N-terminal proline-rich region, a Ras-GTPase binding domain, a PH domain, an SH2 domain and a BPS domain in between the PH and SH2 domains. Human Grb10 gene encodes three splice variants. These variants show differences in functionality. Grb10 associates with multiple proteins including tyrosine kinases in a tyrosine phosphorylation dependent or independent manner. Association with multiple proteins allows Grb10 to regulate different signaling pathways resulting in different biological consequences.

PMID:
24420853
DOI:
10.1007/s11033-014-3046-4
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center