Format

Send to

Choose Destination
Curr Opin Virol. 2014 Feb;4:58-65. doi: 10.1016/j.coviro.2013.12.002. Epub 2014 Jan 14.

Entry of hepatitis B and C viruses - recent progress and future impact.

Author information

1
Inserm U1110, University of Strasbourg and Center for Liver and Digestive Diseases, Strasbourg University Hospitals, 3 Rue Koeberlé, F-67000 Strasbourg, France.
2
Centre for Human Virology, NIHR Centre for Liver Disease, University of Birmingham, Vincent Drive, Birmingham B15 2TT, UK.
3
Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg, ImNeuenheimer Feld 345, D-69120 Heidelberg, Germany.
4
Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg, ImNeuenheimer Feld 345, D-69120 Heidelberg, Germany. Electronic address: stephan.urban@med.uni-heidelberg.de.

Abstract

Chronic hepatitis B and C virus infections are major causes of liver disease and hepatocellular carcinoma worldwide. Although both viruses infect hepatocytes, the molecular virology and cellular biology of their respective replication cycles differ. Viral entry is the first step of the life cycle and recent developments in functional genomic and proteomic methodologies have increased our understanding of the entry pathways for these two important human pathogens. In this review we provide a comparative analysis of the internalization routes for these viruses and highlight differences and how they impact the viral life cycle, immune responses and development of antivirals.

PMID:
24418809
DOI:
10.1016/j.coviro.2013.12.002
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center