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Virology. 2014 Jan 20;449:104-8. doi: 10.1016/j.virol.2013.11.012. Epub 2013 Nov 27.

A case cluster demonstrating the relationship between HLA concordance and virologic and disease outcomes in human immunodeficiency virus infection.

Author information

1
University of California, San Diego, La Jolla, CA, USA; Inserm UMR U966, Tours, France. Electronic address: achaillon@ucsd.edu.
2
University of California, San Diego, La Jolla, CA, USA.
3
University of California, San Diego, La Jolla, CA, USA; Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.

Abstract

We present a detailed analysis of sexual HIV transmission from one source partner to two recipients. The HLA haplotypes between the source partner and one recipient were very similar with 7 out of 8 HLA alleles from four loci (HLA A, B, C and DRB) shared, while the other recipient shared only one allele. The immunologic outcomes between the two recipients differed dramatically, despite the absence of apparent virologic differences in their inoculums. We suggest that non-viral factors, which might be related to differences in the HLA profile, played a role in determining different CD4+ T-cells dynamics for these two recipients.

KEYWORDS:

Cellular immunity; Concordance; Disease progression; Evolution; HLA; Human immunodeficiency virus; Transmission

PMID:
24418543
PMCID:
PMC3895440
DOI:
10.1016/j.virol.2013.11.012
[Indexed for MEDLINE]
Free PMC Article
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