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Autoimmun Rev. 2014 Apr-May;13(4-5):560-4. doi: 10.1016/j.autrev.2013.11.010. Epub 2014 Jan 11.

Diagnosis and classification of autoimmune hemolytic anemia.

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California Polytechnic State University, Department of Biochemistry, San Luis Obispo, CA, United States.
Division of Hematology and Oncology, Department of Internal Medicine, University of California, Davis, Cancer Center, 4501 X St., Suite 3016, Sacramento, CA 95817, United States; Department of Veterans Affairs, Northern California Healthcare System, 150 Muir Road, Martinez, CA 94553, United States. Electronic address:


Uncompensated autoantibody-mediated red blood cell (RBC) consumption is the hallmark of autoimmune hemolytic anemia (AIHA). Classification of AIHA is pathophysiologically based and divides AIHA into warm, mixed or cold-reactive subtypes. This thermal-based classification is based on the optimal autoantibody-RBC reactivity temperatures. AIHA is further subcategorized into idiopathic and secondary with the later being associated with a number of underlying infectious, neoplastic and autoimmune disorders. In most cases AIHA is confirmed by a positive direct antiglobulin test (DAT). The standard therapeutic approaches to treatment of AIHA include corticosteroids, splenectomy, immunosuppressive agents and monoclonal antibodies.

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