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Asian Pac J Trop Med. 2014 Jan;7(1):63-6. doi: 10.1016/S1995-7645(13)60193-5.

Correlation between the Xba I polymorphism of apoB gene and serum lipid profiles in Li ethnic group.

Author information

1
School of Pharmacy, Hainan Medical College, Haikou 571101, P. R. China; Department of Cardiology, People's hospital of Sanya, Sanya 572000, P. R. China.
2
Department of Cardiology, People's hospital of Sanya, Sanya 572000, P. R. China.
3
School of Science, Hainan Medical College, Haikou 571101, P. R. China.
4
Department of Cardiology, People's hospital of Sanya, Sanya 572000, P. R. China; Affliated Hospital of Hainan Medical College, Hainan Medical College, Haikou 571101, P. R. China. Electronic address: yao.zhen@126.com.

Abstract

OBJECTIVE:

To study correlation between the Xba I polymorphism of apoB gene and plasma lipid profiles in Li ethnic group.

METHODS:

Total 151 cases of healthy Li people were recruited randomly by cluster sampling and 200 Han people were recruited as control; blood was drawn to analyze Xba I polymorphism distribution of apoB gene and serum lipid levels.

RESULTS:

There were lower serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels in serum of Li people; while, high density lipoprotein cholesterol (HDL-C), X-/X+ genotype and X+ allele frequencies exhibited higher levels than Han people. Interestingly, HDL-C level was reduced, while LDL-C level was enhanced in subjects carrying heterozygous (X-/X+) genotype compared to homozygous (X-/X-) genotype. Additionally, there were no difference in serum level of triglyceride, TC, apoprotein A (apo A) and apoprotein B (apo B) between Li and Han people, the same results were showed between X-/X+ and X-/X- genotype carriers.

CONCLUSIONS:

Xba I polymorphism of apoB gene is correlated to the profiles of serum lipid level, X-/X+ genotype carriers are phenotyped with higher LDL-C level and lower level of HDL-C in Li ethnic group.

KEYWORDS:

ApoB gene; Li ethnic group; Lipid profile; Xba I polymorphism

PMID:
24418085
DOI:
10.1016/S1995-7645(13)60193-5
[Indexed for MEDLINE]
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