Send to

Choose Destination
See comment in PubMed Commons below
J Med Chem. 2014 Jun 26;57(12):5023-38. doi: 10.1021/jm401490p. Epub 2014 Jan 23.

Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases.

Author information

Pfizer Immunosciences , 200 CambridgePark, Cambridge, Massachusetts 02140, United States.


The Janus kinases (JAKs) are a family of intracellular tyrosine kinases that play an essential role in the signaling of numerous cytokines that have been implicated in the pathogenesis of inflammatory diseases. As a consequence, the JAKs have received significant attention in recent years from the pharmaceutical and biotechnology industries as therapeutic targets. Here, we provide a review of the JAK pathways, the structure, function, and activation of the JAK enzymes followed by a detailed look at the JAK inhibitors currently in the clinic or approved for these indications. Finally, a perspective is provided on what the past decade of research with JAK inhibitors for inflammatory indications has taught along with thoughts on what the future may hold in terms of addressing the opportunities and challenges that remain.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society
    Loading ...
    Support Center