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J Agric Food Chem. 2014 Jan 22;62(3):725-32. doi: 10.1021/jf404220n. Epub 2014 Jan 14.

Preparation of a capsaicin-loaded nanoemulsion for improving skin penetration.

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College of Life Sciences & Biotechnology, Korea University , Anam-dong, Seongbuk-gu, Seoul 136-701, Korea.


Capsaicin o/w nanoemulsions with enhanced skin permeation were successfully prepared by controlling the ratios of the surfactant mixtures, oleoresin capsicum as the oil phase, and aqueous phase. Oleoresin capsicum contains 22.67 mg/g of capsaicin, which is an active and oil-soluble ingredient. Nonionic surfactants, Tween 80 and Span 80, were used to optimize the weight ratio of surfactant mixtures (85.98:14.02) by calculating the hydrophile-lipophile balance (HLB) value. The optimal processing conditions for stable nanoemulsions were investigated by using a ternary phase diagram. The mean droplet size of nanoemulsions ranged from 20 to 62 nm. Skin permeation studies were performed using a Franz diffusion cell. The permeation profiles and confocal laser scanning microscopy (CLSM) images supported that capsaicin nanoemulsion could well permeate all skin layers from the stratum corneum to the dermis. The selected nanoemulsions showed great potential as transdermal delivery carriers for enhancing the permeation of core materials.


HLB value; capsaicin; confocal microscopy; nanoemulsion; skin penetration

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