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Zhong Yao Cai. 2013 Jul;36(7):1123-7.

[Effect of Panax notoginseng saponins on cytokines in liver fibrosis rats].

[Article in Chinese]

Author information

1
First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Grade 3 Laboratory of Traditional Chinese Medicine Preparation, State Administration of TCM, Hefei 230031, China. jhanbing@163.com
2
First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Grade 3 Laboratory of Traditional Chinese Medicine Preparation, State Administration of TCM, Hefei 230031, China.

Abstract

OBJECTIVE:

To observe the effect of Panax notoginseng saponins (PNS) on cytokines production in liver fibrosis rats and its mechanism.

METHODS:

SD rats were randomly divided into 6 groups, including normal group, liver fibrosis model group, PNS (50, 100, 200 mg/kg) treated groups and Col group. Rat liver fibrosis was induced by CCl4 twice a week for 18 weeks. PNS were administered daily from the 9th week for 10 weeks. The IL-1, IL-6, IL-10, TNF-alpha level in serum were determined by radioimmunity. The degree of liver fibrosis was observed by HE and immuninochemistry. The expression of TGF-beta, TNF-alpha mRNA were detected by RT-PCR technology.

RESULTS:

Compared with the fibrotic model group, PNS (100, 200 mg/kg) could not only significantly reduce histopathological change, but also effectively decrease the level of IL-1, IL-6, NF-kappaB, TNF-alpha ,TGF-beta, and increase the level of IL-10.

CONCLUSION:

PNS has protective effect on liver fibrosis and it maybe related to regulating cytokine network.

PMID:
24417151
[Indexed for MEDLINE]
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