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J Bacteriol. 2014 Mar;196(6):1250-6. doi: 10.1128/JB.01090-13. Epub 2014 Jan 10.

Role for Mycobacterium tuberculosis membrane vesicles in iron acquisition.

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1
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.

Abstract

Mycobacterium tuberculosis releases membrane vesicles packed with molecules that can modulate the immune response. Because environmental conditions often influence the production and content of bacterial vesicles, this study examined M. tuberculosis microvesicles released under iron limitation, a common condition faced by pathogens inside the host. The findings indicate that M. tuberculosis increases microvesicle production in response to iron restriction and that these microvesicles contain mycobactin, which can serve as an iron donor and supports replication of iron-starved mycobacteria. Consequently, the results revealed a role of microvesicles in iron acquisition in M. tuberculosis, which can be critical for survival in the host.

PMID:
24415729
PMCID:
PMC3957709
DOI:
10.1128/JB.01090-13
[Indexed for MEDLINE]
Free PMC Article
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