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Clin Infect Dis. 2014 Apr;58(8):1130-9. doi: 10.1093/cid/cit937. Epub 2014 Jan 10.

Long-term immune responses to vaccination in HIV-infected patients: a systematic review and meta-analysis.

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Paris Descartes University.


Vaccine-induced antibodies may wane more quickly in persons living with human immunodeficiency virus (HIV) than in healthy individuals. We reviewed the literature on vaccines routinely recommended in HIV-infected patients to estimate how seroprotection decreases over time in those who initially responded to immunization. For each study retrieved from the literature, the decrease of seroprotection was modeled with a log binomial generalized linear model, and data were pooled in a meta-analysis to provide estimates of seroprotection 2 and 5 years after the last vaccine administration. Our analyses confirmed that the duration of seroprotection was shorter in HIV-infected patients and that with current guidelines, a substantial proportion of patients would have lost protective antibodies before a booster was proposed. We therefore discuss the implications for the monitoring of antibody levels and timing of revaccination in these patients.


HIV; meta-analysis; vaccination

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