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Planta Med. 2014 Jan;80(1):48-55. doi: 10.1055/s-0033-1360171. Epub 2014 Jan 10.

Protective effect of arctigenin against MPP+ and MPTP-induced neurotoxicity.

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1
College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Liaoning, China.
2
College of Life Science and Technology, Dalian University, Liaoning, China.

Abstract

The potential protective effects of arctigenin on 1-methyl-4-phenylpyridinium ion and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyride-induced neurotoxicity were examined, and the results indicated that arctigenin could improve the movement behaviors and upregulate dopamine and γ-aminobutyric acid levels in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyride-induced neurotoxicity mouse model. A further in vitro experiment showed that the pretreatment with arctigenin on cultured human neuroblastoma SH-SY5Y cells could obviously attenuate the decrease of cell survival rates caused by treatment with 1-methyl-4-phenylpyridinium ion by way of acting against cell apoptosis through the decrease of Bax/Bcl-2 and caspase-3, and by antioxidative action through reduction of the surplus reactive oxygen species production and downregulation of mitochondrial membrane potential. It is for the first time that a neuroprotective activity of arctigenin in both in vitro and in vivo experiments was reported, enlightening that arctigenin could be useful as a potential therapeutic agent for Parkinson's disease.

PMID:
24414307
DOI:
10.1055/s-0033-1360171
[Indexed for MEDLINE]
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