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Nat Neurosci. 2014 Feb;17(2):201-3. doi: 10.1038/nn.3623. Epub 2014 Jan 12.

Post-study caffeine administration enhances memory consolidation in humans.

Author information

1
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
2
Department of Chemistry, Johns Hopkins University, Baltimore, Maryland, USA.
3
1] Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland, USA. [2] Department of Neurobiology and Behavior, University of California, Irvine, California, USA.

Abstract

It is currently not known whether caffeine has an enhancing effect on long-term memory in humans. We used post-study caffeine administration to test its effect on memory consolidation using a behavioral discrimination task. Caffeine enhanced performance 24 h after administration according to an inverted U-shaped dose-response curve; this effect was specific to consolidation and not retrieval. We conclude that caffeine enhanced consolidation of long-term memories in humans.

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PMID:
24413697
PMCID:
PMC5909971
DOI:
10.1038/nn.3623
[Indexed for MEDLINE]
Free PMC Article

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