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Graefes Arch Clin Exp Ophthalmol. 2014 Apr;252(4):657-63. doi: 10.1007/s00417-014-2564-z. Epub 2014 Jan 12.

The association between dark adaptation and macular pigment optical density in healthy subjects.

Author information

1
The Vision Centre, Faculty of Life Sciences, University of Manchester, Carys Bannister Building, Manchester, M13 9PL, UK, laura.patryas@manchester.ac.uk.

Abstract

PURPOSE:

To investigate whether macular pigment optical density (MPOD) is related to dark adaptation in healthy subjects.

METHODS:

Dark adaptation was measured after a minimum 30 % pigment bleach in 33 subjects (aged 15-68), using a white 1° stimulus presented 11° below fixation on a cathode ray tube monitor. The luminance range of the monitor was extended using neutral density filters. A heterochromatic flicker photometry based instrument (MPS 9000) was used to measure MPOD.

RESULTS:

The average MPOD for the whole group was 0.37 ± 0.21 optical density units. Subjects with lighter irides had on average 40 % lower MPOD compared to those with darker irides (0.3 ± 0.20 vs 0.5 ± 0.19). Group mean MPOD was weakly associated with second (r = 0.32, p = 0.07) and third rod-mediated recovery rates (r = 0.31, p = 0.08) and with the rod threshold (r = -0.24, p = 0.18) 30 min after the onset of bleach. MPOD was unrelated to cone time constant (r = -0.02, p = 0.91), cone threshold (r = -0.01, p = 0.96), rod-cone break (r = 0.13, p = 0.45) or the rod-rod break (r = 0.11, p = 0.52). The second rod-mediated recovery rate (S2) for the lower 10th percentile of MPOD (n = 4) was 0.18 log cd.m(-2).min(-1) and 0.24 log cd.m(-2).min(-1) for the upper 10th percentile (n = 4). The two groups were significantly different (t = -2.67, p = 0.037).

CONCLUSIONS:

We report a statistically significant difference between subjects falling in the 10th percentile extremes of MPOD and rod-mediated but not cone-mediated sensitivity recovery. Further investigation into the relationship between MPOD and rod function is warranted, particularly extending the work to encompass those with low MPOD and poor night vision.

PMID:
24413682
DOI:
10.1007/s00417-014-2564-z
[Indexed for MEDLINE]

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