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Nat Med. 2014 Feb;20(2):139-42. doi: 10.1038/nm.3445. Epub 2014 Jan 12.

HIV-1 persistence in CD4+ T cells with stem cell-like properties.

Author information

1
1] Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA.
2
1] Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA. [2] Key Laboratory of AIDS Immunology, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China.
3
Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA.
4
Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
5
1] Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA. [2] Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
6
Department of Electrical and Computer Engineering, University of Delaware, Newark, Delaware, USA.
7
1] Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA. [2] Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.
8
Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA.

Abstract

Cellular HIV-1 reservoirs that persist despite antiretroviral treatment are incompletely defined. We show that during suppressive antiretroviral therapy, CD4(+) T memory stem cells (TSCM cells) harbor high per-cell levels of HIV-1 DNA and make increasing contributions to the total viral CD4(+) T cell reservoir over time. Moreover, we conducted phylogenetic studies that suggested long-term persistence of viral quasispecies in CD4(+) TSCM cells. Thus, HIV-1 may exploit the stem cell characteristics of cellular immune memory to promote long-term viral persistence.

Comment in

PMID:
24412925
PMCID:
PMC3959167
DOI:
10.1038/nm.3445
[Indexed for MEDLINE]
Free PMC Article
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