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Int Immunopharmacol. 2014 Mar;19(1):103-9. doi: 10.1016/j.intimp.2013.12.028. Epub 2014 Jan 9.

Zingerone attenuates lipopolysaccharide-induced acute lung injury in mice.

Author information

1
College of Veterinary Medicine, Jilin University, Changchun 130062, PR China.
2
School of Biosciences and Biotechnology, University of Camerino, Camerino, MC 62032, Italy.
3
College of Veterinary Medicine, Jilin University, Changchun 130062, PR China; Département de Médecine Vétérinaire, Institut Supérieur des Sciences et de Médicine Vétérinaire (ISSMV) de Dalaba, Guinea.
4
College of Animal Science, Jilin University, Changchun 130062, PR China. Electronic address: ding_yu@jlu.edu.cn.

Abstract

Zingerone, one of the active components of ginger, is a phenolic alkanone with antioxidant and anti-inflammatory properties. In the present study, we analyzed the role of zingerone against RAW 264.7 cells and acute lung injury induced by lipopolysaccharide (LPS) in mice. RAW cells or BALB/c mice were pretreated with zingerone one hour before stimulated with LPS. We found that zingerone significantly inhibited the production of LPS-induced proinflammatory cytokines in vitro and in vivo. When pretreated with zingerone, pulmonary histopathologic changes, as well as alveolar hemorrhage and neutrophil infiltration were substantially suppressed in lung tissues, with evidence of reduced myeloperoxidase (MPO) activity in murine acute lung injury model. The lung wet-to-dry weight (W/D) ratios, as the index of pulmonary edema, were markedly decreased by zingerone pretreatment. Furthermore, we demonstrated that zingerone attenuates the mitogen-activated protein kinases (MAPK) and nuclear factor-kappaB (NF-κB) signaling pathways through blocking the phosphorylation of ERK, p38/MAPK and IκBα, NF-κB/P65. These results suggest that zingerone may provide protective effects against LPS-induced ALI.

KEYWORDS:

Acute lung injury; Cytokines; Lipopolysaccharide; Zingerone

PMID:
24412620
DOI:
10.1016/j.intimp.2013.12.028
[Indexed for MEDLINE]

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