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Neuron. 2014 Feb 5;81(3):629-40. doi: 10.1016/j.neuron.2013.11.026. Epub 2014 Jan 9.

Structured synaptic connectivity between hippocampal regions.

Author information

1
Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia 20147, USA.
2
Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), 39-1 Hawolgokdong, Seoul, 136-791, Korea.
3
Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), 39-1 Hawolgokdong, Seoul, 136-791, Korea; Neuroscience program, University of Science and Technology, 176 Gajeongdong, Daejeon, 305-350, Korea.
4
Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), 39-1 Hawolgokdong, Seoul, 136-791, Korea; Department of Biological Science, KAIST, 373-1 Guseongdong, Daejeon, 305-701, Korea.
5
Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia 20147, USA. Electronic address: mageej@janelia.hhmi.org.
6
Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), 39-1 Hawolgokdong, Seoul, 136-791, Korea. Electronic address: kimj@kist.re.kr.

Abstract

The organization of synaptic connectivity within a neuronal circuit is a prime determinant of circuit function. We performed a comprehensive fine-scale circuit mapping of hippocampal regions (CA3-CA1) using the newly developed synapse labeling method, mGRASP. This mapping revealed spatially nonuniform and clustered synaptic connectivity patterns. Furthermore, synaptic clustering was enhanced between groups of neurons that shared a similar developmental/migration time window, suggesting a mechanism for establishing the spatial structure of synaptic connectivity. Such connectivity patterns are thought to effectively engage active dendritic processing and storage mechanisms, thereby potentially enhancing neuronal feature selectivity.

PMID:
24412418
DOI:
10.1016/j.neuron.2013.11.026
[Indexed for MEDLINE]
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