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Vaccine. 2014 May 13;32(23):2670-4. doi: 10.1016/j.vaccine.2013.12.037. Epub 2014 Jan 8.

Systematic review of human papillomavirus vaccine coadministration.

Author information

1
Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, United States.
2
Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, United States. Electronic address: dde9@cdc.gov.

Abstract

Human papillomavirus (HPV) vaccination is recommended in early adolescence, at an age when other vaccines are also recommended. Administration of multiple vaccines during one visit is an opportunity to improve uptake of adolescent vaccines. We conducted a systematic review of safety and immunogenicity of HPV vaccines coadministered with other vaccines. Our review included 9 studies, 4 of quadrivalent HPV vaccine and 5 of bivalent HPV vaccine; coadministered vaccines included: meningococcal conjugate, hepatitis A, hepatitis B, combined hepatitis A and B, tetanus, diphtheria, acellular pertussis, and inactivated poliovirus vaccines. Studies varied in methods of data collection and measurement of immunogenicity and safety. Noninferiority of immune response and an acceptable safety profile were demonstrated when HPV vaccine was coadministered with other vaccines.

KEYWORDS:

Coadministration; Concomitant; HPV vaccination; Immunogenicity; Safety

PMID:
24412351
DOI:
10.1016/j.vaccine.2013.12.037
[Indexed for MEDLINE]

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