Format

Send to

Choose Destination
See comment in PubMed Commons below
Neuron. 2014 Jan 8;81(1):130-9. doi: 10.1016/j.neuron.2013.10.043.

Retinal representation of the elementary visual signal.

Author information

1
Systems Neurobiology Laboratories, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address: peter.hawley.li@gmail.com.
2
Systems Neurobiology Laboratories, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Zilkha Neurogenetic Institute, Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
3
Systems Neurobiology Laboratories, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Department of Neuroscience, Carl von Ossietzky University, Oldenburg 26129, Germany.
4
Systems Neurobiology Laboratories, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
5
Institute of Photonics, University of Strathclyde, Glasgow G4 0NW, UK.
6
Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, CA 95064, USA.
7
Systems Neurobiology Laboratories, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Department of Neurosurgery, School of Medicine, Stanford University, Palo Alto, CA 94305, USA.

Erratum in

  • Neuron. 2014 Apr 16;82(2):500.

Abstract

The propagation of visual signals from individual cone photoreceptors through parallel neural circuits was examined in the primate retina. Targeted stimulation of individual cones was combined with simultaneous recording from multiple retinal ganglion cells of identified types. The visual signal initiated by an individual cone produced strong responses with different kinetics in three of the four numerically dominant ganglion cell types. The magnitude and kinetics of light responses in each ganglion cell varied nonlinearly with stimulus strength but in a manner that was independent of the cone of origin after accounting for the overall input strength of each cone. Based on this property of independence, the receptive field profile of an individual ganglion cell could be well estimated from responses to stimulation of each cone individually. Together, these findings provide a quantitative account of how elementary visual inputs form the ganglion cell receptive field.

PMID:
24411737
PMCID:
PMC3951785
DOI:
10.1016/j.neuron.2013.10.043
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center