Format

Send to

Choose Destination
Mol Neurodegener. 2014 Jan 11;9:6. doi: 10.1186/1750-1326-9-6.

Trafficking regulation of proteins in Alzheimer's disease.

Author information

1
Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian 361102, China. yunzhang@xmu.edu.cn.

Abstract

The β-amyloid (Aβ) peptide has been postulated to be a key determinant in the pathogenesis of Alzheimer's disease (AD). Aβ is produced through sequential cleavage of the β-amyloid precursor protein (APP) by β- and γ-secretases. APP and relevant secretases are transmembrane proteins and traffic through the secretory pathway in a highly regulated fashion. Perturbation of their intracellular trafficking may affect dynamic interactions among these proteins, thus altering Aβ generation and accelerating disease pathogenesis. Herein, we review recent progress elucidating the regulation of intracellular trafficking of these essential protein components in AD.

PMID:
24410826
PMCID:
PMC3891995
DOI:
10.1186/1750-1326-9-6
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center