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J Mol Biol. 1987 Feb 20;193(4):661-71.

Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides.

Abstract

Methylation of either of two residues (G-1405 or A-1408) within bacterial 16 S ribosomal RNA results in high level resistance to specific combinations of aminoglycoside antibiotics. The product of a gene that originated in Micromonospora purpurea (an actinomycete that produces gentamicin) gives resistance to kanamycin plus gentamicin by converting residue G-1405 to 7-methylguanosine. Resistance to kanamycin plus apramycin results from conversion of residue A-1408 to 1-methyladenosine catalysed by the product of a gene from Streptomyces tenjimariensis.

PMID:
2441068
DOI:
10.1016/0022-2836(87)90349-4
[Indexed for MEDLINE]

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