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Semin Cell Dev Biol. 2014 Jan-Feb;25-26:71-80. doi: 10.1016/j.semcdb.2013.12.013. Epub 2014 Jan 6.

Evolution and developmental diversity of tooth regeneration.

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Department of Craniofacial Development and Stem Cell Biology, Floor 27 Guy's Tower, Guys Campus, King's College London, SE1 9RT, UK. Electronic address:
Department of Animal and Plant Sciences, Alfred Denny Building, Western Bank, University of Sheffield, S10 2TN, UK. Electronic address:


This review considers the diversity observed during both the development and evolution of tooth replacement throughout the vertebrates in a phylogenetic framework from basal extant chondrichthyan fish and more derived teleost fish to mammals. We illustrate the conservation of the tooth regeneration process among vertebrate clades, where tooth regeneration refers to multiple tooth successors formed de novo for each tooth position in the jaws from a common set of retained dental progenitor cells. We discuss the conserved genetic mechanisms that might be modified to promote morphological diversity in replacement dentitions. We review current research and recent progress in this field during the last decade that have promoted our understanding of tooth diversity in an evolutionary developmental context, and show how tooth replacement and dental regeneration have impacted the evolution of the tooth-jaw module in vertebrates.


Dental lamina; Regeneration; Stem cells; Tooth development; Tooth replacement; Vertebrate diversity

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