Format

Send to

Choose Destination
Gastroenterology. 2014 May;146(6):1534-1546.e3. doi: 10.1053/j.gastro.2014.01.001. Epub 2014 Jan 7.

Gastrointestinal malignancy and the microbiome.

Author information

1
Division of Gastroenterology, Departments of Medicine and Microbiology and Immunology, University of Miami, Miami, Florida.
2
Division of Gastroenterology, Departments of Medicine and Cancer Biology, Vanderbilt University, Nashville, Tennessee. Electronic address: richard.peek@vanderbilt.edu.

Abstract

Microbial species participate in the genesis of a substantial number of malignancies-in conservative estimates, at least 15% of all cancer cases are attributable to infectious agents. Little is known about the contribution of the gastrointestinal microbiome to the development of malignancies. Resident microbes can promote carcinogenesis by inducing inflammation, increasing cell proliferation, altering stem cell dynamics, and producing metabolites such as butyrate, which affect DNA integrity and immune regulation. Studies in human beings and rodent models of cancer have identified effector species and relationships among members of the microbial community in the stomach and colon that increase the risk for malignancy. Strategies to manipulate the microbiome, or the immune response to such bacteria, could be developed to prevent or treat certain gastrointestinal cancers.

KEYWORDS:

Bacteria; Cancer; Inflammation

PMID:
24406471
PMCID:
PMC3995897
DOI:
10.1053/j.gastro.2014.01.001
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center