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Genet Med. 2014 Jul;16(7):535-8. doi: 10.1038/gim.2013.184. Epub 2014 Jan 9.

Horizon scanning for translational genomic research beyond bench to bedside.

Author information

1
1] Kelly Services, Troy, Michigan, USA [2] Epidemiology and Genomics Research Program, National Cancer Institute, Bethesda, Maryland, USA.
2
Epidemiology and Genomics Research Program, National Cancer Institute, Bethesda, Maryland, USA.
3
Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
4
1] Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA [2] McKing Consulting Corporation, Atlanta, Georgia, USA.
5
1] Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA [2] Cadence Group, Atlanta, Georgia, USA.
6
1] Epidemiology and Genomics Research Program, National Cancer Institute, Bethesda, Maryland, USA [2] Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Abstract

PURPOSE:

The dizzying pace of genomic discoveries is leading to an increasing number of clinical applications. In this report, we provide a method for horizon scanning and 1 year data on translational research beyond bench to bedside to assess the validity, utility, implementation, and outcomes of such applications.

METHODS:

We compiled cross-sectional results of ongoing horizon scanning of translational genomic research, conducted between 16 May 2012 and 15 May 2013, based on a weekly, systematic query of PubMed. A set of 505 beyond bench to bedside articles were collected and classified, including 312 original research articles; 123 systematic and other reviews; 38 clinical guidelines, policies, and recommendations; and 32 articles describing tools, decision support, and educational materials.

RESULTS:

Most articles (62%) addressed a specific genomic test or other health application; almost half of these (n = 180) were related to cancer. We estimate that these publications account for 0.5% of reported human genomics and genetics research during the same time.

CONCLUSION:

These data provide baseline information to track the evolving knowledge base and gaps in genomic medicine. Continuous horizon scanning of the translational genomics literature is crucial for an evidence-based translation of genomics discoveries into improved health care and disease prevention.

PMID:
24406461
PMCID:
PMC4079725
DOI:
10.1038/gim.2013.184
[Indexed for MEDLINE]
Free PMC Article
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