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Eye (Lond). 2014 Mar;28(3):337-43. doi: 10.1038/eye.2013.296. Epub 2014 Jan 10.

Role of lens vault in subtypes of angle closure in Iranian subjects.

Author information

1
1] Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran [2] Glaucoma Division, Jules Stein Eye Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA [3] Koret Vision Center, University of California, San Francisco Medical School, San Francisco, CA, USA.
2
Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran.
3
Glaucoma Division, Jules Stein Eye Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
4
Koret Vision Center, University of California, San Francisco Medical School, San Francisco, CA, USA.

Abstract

PURPOSE:

The purpose of this study is to quantify anterior chamber (AC) parameters and to determine the proportion of eyes with exaggerated lens vault (LV) in different subtypes of angle closure disease using anterior segment optical coherence tomography (AS-OCT).

PATIENTS AND METHODS:

In this prospective study, 115 eyes of 115 Iranian patients with angle closure disease were included and categorized into three groups: (1) fellow eyes of acute angle closure (AAC; 40 eyes); (2) primary angle closure glaucoma (PACG; 39 eyes); and (3) primary angle closure suspect (PACS; 36 eyes). Complete ophthalmic examination including gonioscopy, A-scan biometry, and AS-OCT were performed. Angle parameters, LV, and iris thickness (IT) were measured using AS-OCT. An exaggerated LV was defined as LV more than one-third the distance between the corneal endothelium and a line drawn to connect the nasal and temporal scleral spurs.

RESULTS:

Fellow eyes of AAC had the shallower AC (P=0.01), greater iris curvature (I-curve; P=0.01), and higher LV (P=0.02) as compared with PACS and PACG eyes. There was no statistically significant difference in the mean IT at 750 μm from scleral spur among the three groups (P=0.45). Exaggerated LV was found in 67.5, 35.9, and 40% of fellow eyes of AAC, PACG, and PACS, respectively, (P=0.008) with an odds ratio of 1.92 (P=0.005) for fellow vs PACG and 1.68 (P=0.01) for fellow vs PACS.

CONCLUSIONS:

Exaggerated LV is highly prevalent in fellow eyes of AAC. These eyes have shallower AC depth, greater I-curve, and higher LV when compared with PACG and PACS.

PMID:
24406416
PMCID:
PMC3965822
DOI:
10.1038/eye.2013.296
[Indexed for MEDLINE]
Free PMC Article

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