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Curr Biol. 2014 Jan 6;24(1):R25-R27. doi: 10.1016/j.cub.2013.11.016.

Circadian clocks: the tissue is the issue.

Author information

1
Department of Biology and Center for Biological Clocks Research, Texas A&M University, College Station, TX 77843-3258, USA.
2
Department of Biology and Center for Biological Clocks Research, Texas A&M University, College Station, TX 77843-3258, USA. Electronic address: phardin@bio.tamu.edu.

Abstract

The circadian clock uses a widely expressed pair of clock activators to drive tissue-specific rhythms in target gene expression. A new study sheds light on this tissue specificity by showing that binding of clock activators and tissue-specific transcription factors to closely associated target sites enables cooperative activation of target genes in different tissues.

PMID:
24405673
PMCID:
PMC4157344
DOI:
10.1016/j.cub.2013.11.016
[Indexed for MEDLINE]
Free PMC Article

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