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PLoS One. 2014 Jan 3;9(1):e84086. doi: 10.1371/journal.pone.0084086. eCollection 2014.

Local plasticity of dendritic excitability can be autonomous of synaptic plasticity and regulated by activity-based phosphorylation of Kv4.2.

Author information

1
Nano-scale Science and Engineering Center, Berkeley, California, United States of America ; Biophysics Program, University of California Berkeley, California, United States of America.
2
Nano-scale Science and Engineering Center, Berkeley, California, United States of America.

Abstract

While plasticity is typically associated with persistent modifications of synaptic strengths, recent studies indicated that modulations of dendritic excitability may form the other part of the engram and dynamically affect computational processing and output of neuronal circuits. However it remains unknown whether modulation of dendritic excitability is controlled by synaptic changes or whether it can be distinct from them. Here we report the first observation of the induction of a persistent plastic decrease in dendritic excitability decoupled from synaptic stimulation, which is localized and purely activity-based. In rats this local plasticity decrease is conferred by CamKII mediated phosphorylation of A-type potassium channels upon interaction of a back propagating action potential (bAP) with dendritic depolarization.

PMID:
24404150
PMCID:
PMC3880279
DOI:
10.1371/journal.pone.0084086
[Indexed for MEDLINE]
Free PMC Article

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