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J Infect Dis. 2014 Jun 15;209(12):2012-6. doi: 10.1093/infdis/jiu009. Epub 2014 Jan 7.

Massive mobilization of dendritic cells during influenza A virus subtype H5N1 infection of nonhuman primates.

Author information

1
Center for Vaccine Research.
2
Department of Pathology.
3
Department of Infectious Disease and Microbiology.
4
Center for Vaccine Research Department of Microbiology and Molecular Genetics.
5
Center for Vaccine Research Department of Infectious Disease and Microbiology Department of Immunology, University of Pittsburgh, Pennsylvania.

Abstract

Highly pathogenic avian influenza virus infection is characterized by a marked inflammatory response, but the impact of infection on dendritic cells (DCs) is unknown. We show that influenza A virus subtype H5N1 infection rapidly and profoundly impacts DCs in cynomolgus macaques, increasing the number of blood myeloid and plasmacytoid DCs by 16- and 60-fold, respectively. Infection was associated with recruitment, activation, and apoptosis of DCs in lung-draining lymph nodes; granulocyte and macrophage infiltration in lungs was also detected, together with expression of CXCL10. This degree of DC mobilization is unprecedented in viral infection and suggests a potential role for DCs in the pathogenesis of highly pathogenic avian influenza virus.

KEYWORDS:

cynomolgus macaque; highly pathogenic avian influenza; inflammation; innate immunity; viral pathogenesis

PMID:
24403559
PMCID:
PMC4038140
DOI:
10.1093/infdis/jiu009
[Indexed for MEDLINE]
Free PMC Article
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