miR-30c-2-3p and miR-30a-3p: new pieces of the jigsaw puzzle in HIF2α regulation

Holger Moch; Magdalena Lukamowicz-Rajska

doi:10.1158/2159-8290.CD-13-0897

miR-30c-2-3p and miR-30a-3p: new pieces of the jigsaw puzzle in HIF2α regulation

Cancer Discov. 2014 Jan;4(1):22-4. doi: 10.1158/2159-8290.CD-13-0897.

Authors

Holger Moch¹, Magdalena Lukamowicz-Rajska

Affiliation

¹ Institute of Surgical Pathology, University Hospital Zürich, Zürich, Switzerland.

PMID: 24402943
DOI: 10.1158/2159-8290.CD-13-0897

Abstract

Clear cell renal cell carcinoma (ccRCC), the most frequent subtype of renal cell cancer, is characterized by mutation of the von Hippel-Lindau (VHL) tumor suppressor gene, which results in stabilization of hypoxia-inducible factor (HIF) α proteins. In this issue of Cancer Discovery, Mathew and colleagues report that miR-30c-2-3p and miR-30a-3p downregulation in ccRCC promotes increased expression of HIF2α.

MeSH terms

Basic Helix-Loop-Helix Transcription Factors / metabolism*
Carcinoma, Renal Cell / genetics
Carcinoma, Renal Cell / metabolism*
Humans
Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
Kidney Neoplasms / genetics
Kidney Neoplasms / metabolism*
MicroRNAs / metabolism*
Von Hippel-Lindau Tumor Suppressor Protein / metabolism

Substances

Basic Helix-Loop-Helix Transcription Factors
HIF1A protein, human
Hypoxia-Inducible Factor 1, alpha Subunit
MIRN30b microRNA, human
MicroRNAs
endothelial PAS domain-containing protein 1
Von Hippel-Lindau Tumor Suppressor Protein
VHL protein, human