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Braz J Psychiatr. 2013 Oct-Dec;35(4):380-6. doi: 10.1590/1516-4446-2012-0886. Epub 2013 Dec 23.

Acute and chronic administration of cannabidiol increases mitochondrial complex and creatine kinase activity in the rat brain.

Author information

1
Laboratory of Neurosciences and National Science and Technology Institute for Translational Medicine (INCT-TM), Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense (UNESC), CriciúmaSC, Brazil.
2
Laboratory of Experimental Pathophysiology and INCT-TM, Graduate Program in Health Sciences, Health Sciences Unit, UNESC, CriciúmaSC, Brazil.
3
Department of Neurosciences and Behavior, Division of Psychiatry, Ribeirão Preto Medical School, Universidade de São Paulo (USP), and INCT-TM, Ribeirão PretoSP, Brazil.

Abstract

OBJECTIVE:

To investigate the effects of cannabidiol (CBD) on mitochondrial complex and creatine kinase (CK) activity in the rat brain using spectrophotometry.

METHOD:

Male adult Wistar rats were given intraperitoneal injections of vehicle or CBD (15, 30, or 60 mg/kg) in an acute (single dose) or chronic (once daily for 14 consecutive days) regimen. The activities of mitochondrial complexes and CK were measured in the hippocampus, striatum, and prefrontal cortex.

RESULTS:

Both acute and chronic injection of CBD increased the activity of the mitochondrial complexes (I, II, II-III, and IV) and CK in the rat brain.

CONCLUSIONS:

Considering that metabolism impairment is certainly involved in the pathophysiology of mood disorders, the modulation of energy metabolism (e.g., by increased mitochondrial complex and CK activity) by CBD could be an important mechanism implicated in the action of CBD.

PMID:
24402213
DOI:
10.1590/1516-4446-2012-0886
[Indexed for MEDLINE]
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